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KMID : 0357919790130020083
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Korean Journal of Pathology
1979 Volume.13 No. 2 p.83 ~ p.94
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A Study on Hemoglobin Electrophoresis in Healthy Adult Persons, Newborns at Birth and Patients with Anemic Diseases
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Abstract
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The author investigated hemoglobin types in the peripheral blood obtained from
antecubital vein of 90 cases of the healthy adult persons and 18 cases of the patients
with anemia, and in the cord blood of 30 cases of the newborns at birth.
The patients with anemia consisted of 6 cases of iron deficiency anemia, 6 cases of
aplastic anemia and 6 cases of malignant tumor associated with anemia. The hemoglobin
concentration estimated by cyanmethemoglobin method and the hemoglobin types
estimated by cellulose acetate electrophoresis.
The results obtained were summarized as follows :
1. In the healthy adult persons, the mean hemoglobin concentration was 16.0±1.2g/dl
in male and 14.4±1.3g/dl in female. The mean percentages of HbA and HbA
2 were 96.83±0.58 and 3.12±0.58%, respectively.
2. In the newborns at birth, the mean hemoglobin concentration was 16.7±1.5g/dl and
the mean percentages of HbA and HbF were 27.3±5.5% and 72.7±5.5%, respectively.
3. In the patients with aplastic anemia, the mean percentages of HbA, HbA2
and HbF were 93.7±1.7, 2.6±0.4% and 4.2±1.8%, respectively. The mean
percentage of HbF in the patients with aplastic anemia was significantly increased than
that in the healthy adult persons, while the mean percentages of HbA and HbA2
were significantly decreased.
4. In the patients with iron deficiency anemia, the mean percentages of HbA and
HbA2 were 97.6±0.4 and 2.4±0.4%, respectively. The mean percentage of
HbA in the patient with iron deficiency anemia was significantly increased than that in
the healthy adult persons, while the mean percentage of HbA2 was
significantly decreased.
5. In the anemia patients with malignancy, the mean percentages of HbA and HbA
2 were 96.8±0.78% and 3.2±0.78%, respectively. And the mean percen-
tages of HbA and HbA2 were not significantly different between the
healthy adult persons and the anemia patients with malignancy.
According to these results, it may be somewhat helpful to estimate the hemoglobin
types in the diagnosis and treatment of aplastic anemia and iron deficiency anemia.
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